ПРОТЕОМНЫЕ ТЕХНОЛОГИИ И РАЗВИТИЕ БИОИНФОРМАЦИОННЫХ РЕСУРСОВ (ОБЗОР)

Аннотации. В обзорной статье представлены современные сведения о протеомных и биоинформационных технологиях развития биохимии белков. Показано, что кодирующая емкость матричной ДНК не может полностью обеспечить митохондрий в белках. Приведены сведения о том, что существует пять различных механизмов импорта белков в митохондрии. Приведены сведения о том, что существуют ограничения вычислительных технологий, которые заключаются в большом проценте ложноположительных результатов, а также в невозможности обнаружения таргет-сигналов для всего протеома. Показаны преимущества тандемной масс-спектрометрии для проведения такого рода исследований. Также, к успешно применяемым подходам по локализации белков можно отнести методы микроскопии, при которых используется принцип иммунофлуоресценции нативных белков. Приведены данные об основных свойствах протеомных белков.

матричная ДНК, белки, митохондрии, протеомы, диагностика, matrix DNA, proteins, mitochondrions, proteoms, diagnostics

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