EXPRESSION OF LEPTIN IN BREAST CANCER PATIENTS
Abstract
Analysis of hormone leptin (LEP) concentrations
in blood serum and tumor tissue of 58 patients of
reproductive age with different clinical characteristics of
breast cancer (BC) has been made. It was found by ELISA,
that LEP level in patients with rapid malignant tumor
growth is higher than in ones with mammary fibroadenoma
or in donor sera. The correlation between LEP andLEPR
gene expression was revealed by RT PCR and immunohistochemical
tissue staining in malignant mammary tumors
and triple negative BC. The data obtained have shown the
possible association between high LEP sera level and tumor
progression.
in blood serum and tumor tissue of 58 patients of
reproductive age with different clinical characteristics of
breast cancer (BC) has been made. It was found by ELISA,
that LEP level in patients with rapid malignant tumor
growth is higher than in ones with mammary fibroadenoma
or in donor sera. The correlation between LEP andLEPR
gene expression was revealed by RT PCR and immunohistochemical
tissue staining in malignant mammary tumors
and triple negative BC. The data obtained have shown the
possible association between high LEP sera level and tumor
progression.
About the Authors
Е. Передереева
Российский онкологический центр им. Н.Н. Блохина РАМН (г. Москва)
Russian Federation
Russian Federation
С. Клунова
Московский педагогический государственный университет
Russian Federation
Russian Federation
А. Параконная
Российский онкологический центр им. Н.Н. Блохина РАМН (г. Москва)
Russian Federation
Russian Federation
А. Фрыкин
Московский педагогический государственный университет
Russian Federation
Russian Federation
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