Influence panavir on electroencephalogram of human brain
Abstract
The effect of intranasal Panavir (200 mcg / 0.2
ml) administration on the EEG of healthy volunteers was
investigated in a blind paired study. Panavir and placebo
were injected alternately with intervals of 30 days without
informing the persons about the nature of the injected
substance. EEG was recorded before and after 10 and
120 minutes and 24 hours after the substance treatment.
Some differences in the Panavir and placebo effects were
revealed. 10 min after the introduction of short-term placebo
indicated an increase in EEG power spectrum in the
range of theta- and beta-waves, 2 hours later - a decrease
of spectral power in theta- and beta- bands, and 24 hours
- only a reduction of spectral power in the theta-range. The
feature of the Panavir EEG effect which is observed after
2 hours is a steady decline in spectral power in a narrow
range of beta-activity noted during the observation time,
and increased alpha-rhythm in occipital cortex 24 h after
Panavir injection which may indicate that normalization of
the EEG in this period.
ml) administration on the EEG of healthy volunteers was
investigated in a blind paired study. Panavir and placebo
were injected alternately with intervals of 30 days without
informing the persons about the nature of the injected
substance. EEG was recorded before and after 10 and
120 minutes and 24 hours after the substance treatment.
Some differences in the Panavir and placebo effects were
revealed. 10 min after the introduction of short-term placebo
indicated an increase in EEG power spectrum in the
range of theta- and beta-waves, 2 hours later - a decrease
of spectral power in theta- and beta- bands, and 24 hours
- only a reduction of spectral power in the theta-range. The
feature of the Panavir EEG effect which is observed after
2 hours is a steady decline in spectral power in a narrow
range of beta-activity noted during the observation time,
and increased alpha-rhythm in occipital cortex 24 h after
Panavir injection which may indicate that normalization of
the EEG in this period.
About the Authors
С. Стовбун
Институт химической физики имени Н.Н. Семенова РАН
Russian Federation
Russian Federation
Дмитрий Сафронов
Институт химической физики имени Н.Н. Семенова РАН
Russian Federation
Russian Federation
Талех Фарзалиев
Институт химической физики имени Н.Н. Семенова РАН
Russian Federation
Russian Federation
Л. Неробкова
Учреждение Российской академии медицинских наук
Научно-исследовательский институт фармакологии имени В.В. Закусова РАМН
Russian Federation
Russian Federation
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