Contents lovastatin in different strains aspergillus terreus
Abstract
30 strains of filamentous fungi Aspergillus
terreus, isolated from different soil samples (red soil,
the peel of salt with soil ) in Uzbekistan, as potential
producers of lovastatin and related compounds have
been studied. Four active strains of investigated sample
have been found. One of them together with lovastatin
is capable to produce small amounts of simvastatin.
Original content of lovastatin in the biomass of active
strains gives grounds to consider them quite promising
for this purpose
terreus, isolated from different soil samples (red soil,
the peel of salt with soil ) in Uzbekistan, as potential
producers of lovastatin and related compounds have
been studied. Four active strains of investigated sample
have been found. One of them together with lovastatin
is capable to produce small amounts of simvastatin.
Original content of lovastatin in the biomass of active
strains gives grounds to consider them quite promising
for this purpose
About the Authors
Ташхан Гулямова
Институт микробиологии АН Узбекистана
Russian Federation
Russian Federation
Диларам Рузиева
Институт микробиологии АН Узбекистана
Russian Federation
Russian Federation
Саодат Насметова
Институт микробиологии АН Узбекистана
Russian Federation
Russian Federation
Феруза Каримова
Институт микробиологии АН Узбекистана
Russian Federation
Russian Federation
Гульчехра Расулова
Институт микробиологии АН Узбекистана
Russian Federation
Russian Federation
Ксения Лобанова
Институт микробиологии АН Узбекистана
Russian Federation
Russian Federation
Панах Мурадов
Институт микробиологии НАН Азербайджана
Russian Federation
Russian Federation
References
1. Alberts AW, Chen J, Kuron G, Hunt V. et al . Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and cholesterol-lowering agent. Proc Natl Acad Sci USA. 1980. Vol.77. P. 3957-3961.
2. Demain A.L. Pharmaceutically active secondary metabolites of microorganisms // Appl Microbiol Biotechnol., 1999 V.52. P.455-463.
3. Hajjaj H., Niederberger P, Duboc P. Lovastatin biosynthesis by Aspergillius tereus in chemically defined medium//Appl.Environ.Microbiol. 2001. V.67, P.2596-2602
4. Barrios-Gonzales J., Miranda R.U. Biotechnological production and applications of statins // Appl Microbiol Biotechnol. 2010. V.85. N 4. P.869-83.
5. M. Manzoni, Rollini М. Biosynthesis and biotechnological production of statins by fi lamentous fungi and application of these cholesterol -lowering drugs // Appl.Microbiol.Biotechnol. 2002. V.58. P.555-564.
6. Daborah RA, Lein J., Conder MJ, Tewalt GL. Enzymatic deacetylation of simvastatin. British Patent GB2255974(1992).
7. Kumar M.S, Pallapothu Mahendra Kumar, Hemant M. Sarnalik. A rapid technique for screening of lovastatin-producing strains of Aspergillus terreus by agar plug and Neurospora crassa bioassay//Journal of Microbiological Methods. 2000. V.40. P.99-10.
8. Lopez С.J.L., Sanchez Perez J.A., Fernandez Sevilla J.M., Acien Fernandez F.G., Molina Grima E., Chisti Y. Fermentation optimization for the production of lovastatin by Aspergillus terreus: use of response surface methodology // Journal of Chem.Technol. Biotechnol. 2004. V.79. P.1119-1126.
9. Manzoni M. Rollini M., Bergomi S., Cavazzoni V. Production and purifi cation of statins from Aspergillus terreus strains//Biotechnol. Technigues. 1998. V.12. P.529-532.
10. Friedrich J., Zuzek M., Bencina M., Cimerman A., Strancar A., Radez I. High performance liquid chromatographic analysis of mevinolin as mevinolinic acid in fermentation broths//J. Chromatogr. 1996. V. 704. P.363-367.
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