geomgouГеографическая среда и живые системыGeographical Environment and Living Systems2712-76132712-7621Московский государственный областной университетgeomgou-469Research ArticleБИОЛОГИЯПРОТЕОМНЫЕ ТЕХНОЛОГИИ И РАЗВИТИЕ БИОИНФОРМАЦИОННЫХ РЕСУРСОВ (ОБЗОР)PROTEOMIC TECHNOLOGIES AND DEVELOPMENT BIOINFORMATION RESOURCESСнисаренкоТатьяна АлександровнаSnisarenkoT. .snisarenko_t@rambler.ruРасуловРизо МаксудовичRasulovR. .rizo_rasulov@mail.ruСусоваМария ИгоревнаSusovaM. .Mary-22@yandex.ruРасуловМаксуд МухамеджановичRasulovM. .maksud@bk.ruМосковский государственный областной университетРоссияMoscow State Regional UniversityRussian FederationГосударственный ордена Трудового Красного Знамени «ГНИИ химии и технологии элементоорганических соединений»РоссияState Scientific Center of the Russian Federation, Federal State Unitary Enterprise «State Scientific Research Institute of Chemistry and Technology of Organoelement Compounds»Russian Federation201406052022025872Copyright © Снисаренко Т.А., Расулов Р.М., Сусова М.И., Расулов М.М., 20222022Снисаренко Т.А., Расулов Р.М., Сусова М.И., Расулов М.М.Snisarenko T..., Rasulov R..., Susova M..., Rasulov M...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geoecosreda.ru/jour/article/view/469

Аннотации. В обзорной статье представлены современные сведения о протеомных и биоинформационных технологиях развития биохимии белков. Показано, что кодирующая емкость матричной ДНК не может полностью обеспечить митохондрий в белках. Приведены сведения о том, что существует пять различных механизмов импорта белков в митохондрии. Приведены сведения о том, что существуют ограничения вычислительных технологий, которые заключаются в большом проценте ложноположительных результатов, а также в невозможности обнаружения таргет-сигналов для всего протеома. Показаны преимущества тандемной масс-спектрометрии для проведения такого рода исследований. Также, к успешно применяемым подходам по локализации белков можно отнести методы микроскопии, при которых используется принцип иммунофлуоресценции нативных белков. Приведены данные об основных свойствах протеомных белков.

In a review modern data on proteomic and bioinformation technologies of development of biochemistry of proteins are presented. It is shown that the coding capacity of matrix DNA cannot provide completely mitochondria’s in proteins. Data that there are five various mechanisms of import of proteins in a mitochondrion are given. Data that there are restrictions of computing technologies which consist in big percent of the false positive results, and also in impossibility of detection of target-signals for everything proteom are given. Advantages of tandem mass spectrometry to carrying out such researches are shown. Also, on localization of proteins it is possible to carry microscopy methods at which the principle of immunofluorescence of nature proteins is used to successfully applied approaches. Data on the main properties of proteoms proteins are provided.

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The authors declare that there are no conflicts of interest present.